Nicolette: 0:01

Welcome to the Health Pulse, your go-to source for quick, actionable insights on health, wellness and diagnostics. Whether you're looking to optimize your well-being or stay informed about the latest in medical testing, we've got you covered. Join us as we break down key health topics in just minutes. Let's dive in.

Rachel: 0:25

Welcome to the Deep Dive. I just saw this statistic that, honestly, kind of stopped me in my tracks.

Mark: 0:31

Oh yeah, what was it?

Rachel: 0:32

Get this Autoimmune diseases they're affecting over 50 million Americans.

Mark: 0:40

Wow, 50 million, that's huge.

Rachel: 0:42

Right, and here's the kicker they're a leading cause of chronic illness, especially in women. And you know, for ages it felt like, well, that's just bad luck, right? Genetic lottery.

Mark: 0:51

Yeah, the bad genes explanation.

Rachel: 0:53

Exactly, but the science is really painting a different picture. Now. It seems like environmental triggers, and especially our diet, are massive drivers.

Mark: 1:02

That's the really interesting part, isn't it? It shifts the focus. If environment, if diet plays such a big role, well, it kind of blows things open for understanding and maybe, more importantly, for actually doing something.

Rachel: 1:13

Precisely so that's what we're digging into today. We're looking at a surprisingly overlooked factor here High carbohydrate diets.

Mark: 1:21

The typical Western diet stuff.

Rachel: 1:23

Yeah, Our mission today is to unpack how all these refined sugars, these processed starches, how they do more than just spike your blood sugar. We're talking about fundamentally changing your gut bacteria, fueling inflammation system-wide and basically pushing your immune system into like attack mode against itself.

Mark: 1:42

Which leads to a really powerful idea. If your diet can be a trigger, maybe it can also be part of the fix.

Rachel: 1:53

Exactly so. For anyone listening who's living with an autoimmune condition or maybe even suspects they might have one, understanding this link, it's pretty crucial. Your diet could literally be, you know, feeding the fire or maybe calming the storm.

Mark: 2:03

Okay, so let's start peeling back those layers. Where do we begin?

Rachel: 2:06

Right. So just a quick refresher, though many listeners will know this Autoimmune disorders happen when your own immune system gets confused. It starts attacking your body's own healthy tissues.

Mark: 2:15

Instead of just going after like viruses or bacteria, it misidentifies friend from foe.

Rachel: 2:20

Yeah, and that leads to this chronic activation, loads of inflammation and actual tissue damage.

Mark: 2:25

And it's not just one or two rare diseases. We're talking over 100 different recognized autoimmune conditions A hundred, wow yeah, affecting pretty much any part of the body. You know the common ones like Hashimoto's, thyroiditis, rheumatoid arthritis, lupus, ms, psoriasis, even things like Crohn's and colitis, the inflammatory bowel diseases. It's a really wide spectrum.

Rachel: 2:48

That's huge and OK. Genetics we always hear about genes, right, but how much is just genes?

Mark: 2:54

Well, that's where it gets interesting. The NIH data looking at identical twins people with basically the same DNA shows genes only account for about maybe one third of the risk.

Rachel: 3:05

Only a third. So what's the rest?

Mark: 3:07

The other two thirds, that's mostly environmental and lifestyle triggers.

Rachel: 3:10

Ah, okay, like what.

Mark: 3:12

Things like diet, obviously, which we're focusing on, but also gut health infections. People have had stress levels, exposure to toxins, even hormonal shifts. It really broadens the picture.

Rachel: 3:22

It gives you more levers to pull, potentially.

Mark: 3:24

Exactly More agency.

Rachel: 3:26

So, across all these different diseases, what's the common threat? You mentioned inflammation.

Mark: 3:30

Yeah, chronic inflammation is really the hallmark. It's like the immune system is just stuck in the on position, constantly activated, bleeding too Well, tissue destruction, those awful cycles of flare-ups and then maybe remission and all those symptoms, symptoms. People struggle with the fatigue, the joint pain, skin issues, that really frustrating brain fog.

Rachel: 3:50

OK, so this sets up a really crucial idea, then.

Mark: 3:53

Which is.

Rachel: 3:53

That the metabolic environment you create, largely through your diet, directly shapes how your immune system actually behaves.

Mark: 3:59

Bingo, and that's the perfect lead in to talking about carbohydrates.

Rachel: 4:03

Right, so we know what autoimmunity is generally. Now let's get to the how. How do carbs specifically fuel this whole inflammatory mess? Because I mean, not all carbs are bad, surely?

Mark: 4:15

No, definitely not. It's really about the type of carb, the amount and how often you're eating them. That's what really influences the immune system.

Rachel: 4:23

Okay, so what happens with the bad guys, the refined stuff?

Mark: 4:26

Well, think about eating white bread, sugary cereals, sodas, processed snacks. Those cause really rapid big spikes in your blood glucose.

Rachel: 4:34

Your blood sugar shoots up.

Mark: 4:35

Right and your body pumps out insulin to deal with it. But if that happens over and over, day after day, your cells can become less responsive to that insulin. That's insulin resistance.

Rachel: 4:45

And insulin resistance isn't just about blood sugar, is it?

Mark: 4:50

no-transcript. Chronically high blood sugar and insulin. They're directly linked to higher levels of pro-inflammatory messengers, things called cytokines, like IL-6, TNF-alpha and C-reactive protein or CRP.

Rachel: 5:04

And those are the things doctors often measure in autoimmune conditions.

Mark: 5:08

Exactly. They're often elevated in lupus, RA, Hashimoto's, you name it. Plus, high blood sugar creates something called oxidative stress.

Rachel: 5:15

Okay, what's?

Mark: 5:15

that it generates these unstable molecules reactive oxygen species, ros for short. They damage cells and basically poke the immune system, potentially activating those immune cells that mistakenly attack your own body.

Rachel: 5:27

So insulin resistance is like this, this hidden engine driving the inflammation.

Mark: 5:31

You can definitely see it that way. It messes with immune cell signals, promotes belly fat, which itself releases inflammatory stuff. And here's something really key NIH research shows lots of people with autoimmune diseases have underlying insulin resistance, even if they're not overweight.

Rachel: 5:49

Wow, so it's not just about weight. That's a really important point.

Mark: 5:52

Absolutely crucial. Metabolic health and immune health are just deeply intertwined, which brings us neatly to the gut microbiome.

Rachel: 6:00

Ah the gut. Everything seems to come back to the gut these days.

Mark: 6:03

Well, there's a good reason. A disrupted gut microbiome, an imbalance in your gut bacteria, can really cause the immune system to go haywire.

Rachel: 6:11

Okay. So how do refined carbs specifically mess with our gut bugs?

Mark: 6:16

Think of your gut like a garden Refined sugars and starches. They're like super fertilizer for the weeds, the pro-inflammatory, potentially pathogenic microbes like certain yeasts, candida or bacteria klebsiella.

Rachel: 6:28

And they starve, the good guys.

Mark: 6:29

Pretty much. They don't feed the beneficial species like acromantia or bifidobacteria which we need for a healthy gut lining and immune balance. This imbalance is called gut dysbiosis.

Rachel: 6:40

Okay, dysbiosis, and that leads to.

Mark: 6:44

It promotes gut permeability. You've probably heard it called leaky gut.

Rachel: 6:48

Right leaky gut, so the gut lining gets weaker.

Mark: 6:51

Exactly and when it's leaky, things that should stay inside the gut, like bacterial toxins, especially one called lipopolysaccharide or LPS, can slip into the bloodstream and the immune system sees those toxins and freaks out. It triggers a big immune response, more inflammation, and it can contribute to the immune system losing its ability to tolerate your own tissues that loss of self-tolerance we talked about your own tissues, that loss of self-tolerance we talked about.

Rachel: 7:16

So the leaky gut literally lets trouble into the bloodstream. You mentioned molecular mimicry earlier. How does that fit in? Sounds complicated.

Mark: 7:22

It's kind of like a case of mistaken identity. Sugars can increase a protein called zonulin. More zonulin means looser connections between gut cells, hence more leakiness. Okay, so undigested food bits, bacterial bits, toxins get through. The immune system flags them as invaders, but sometimes the molecular structure of that invader looks very similar to some of your own body's tissues.

Rachel: 7:45

So the immune system learns to attack the invader.

Mark: 7:47

And then it accidentally starts attacking your own cellular looking tissues too. That's molecular mimicry too. That's molecular mimicry. We see potential links like gluten or casein exposure potentially triggering Hashimoto's in susceptible people, or gut-derived LPS worsening RA, or certain microbes possibly linked to MS or lupus flares.

Rachel: 8:07

That's fascinating and kind of scary. And you also mentioned the gut-brain link. How does that play into autoimmune symptoms like brain fog or fatigue?

Mark: 8:15

Yeah, the gut-brain-immune axis is huge. The microbes in your gut actually communicate with your brain, so dysbiosis and inflammation in the gut can directly impact mood, energy, focus, contributing to that awful brain fog, anxiety and crushing fatigue that so many autoimmune patients experience.

Rachel: 8:33

Wow, okay, so it's clear how these carbs can cause problems metabolically and in the gut. What's the actual research evidence linking this Western diet pattern to the rise in autoimmunity? Is it solid?

Mark: 8:43

It's definitely getting more solid all the time. Yeah, there's a growing body of work. Several studies now link that typical Western diet, high in refined carbs, sugar processed foods, with a higher prevalence of autoimmune conditions.

Rachel: 8:53

Any specific examples.

Mark: 8:55

Sure, there was a big review back in 2017 in Frontiers in Immunology. It specifically pointed to diet-driven changes in the gut microbiome and the gut lining integrity as key environmental triggers for things like IBD, lupus and MS.

Rachel: 9:12

Okay, so connecting the diet, the gut and the disease.

Mark: 9:15

Exactly. And another study this one connecting the diet, the gut and the disease, exactly. And another study this one in the journal Nutrients confirmed that diets high in ultra-processed carbs directly mess up the gut, barrier function and promote immune dysregulation.

Rachel: 9:26

And animal studies too.

Mark: 9:28

Yeah, there are animal models too. Studies showing high-glucose diets actually make autoimmune symptoms worse. In models designed to mimic conditions like lupus and rheumatoid arthritis, they see increased inflammatory markers, more immune activation. It connects the dots pretty directly from the sugar to the inflammation.

Rachel: 9:44

Okay, so that's the problem side. What about solutions? Does research show that cutting back on these carbs actually helps?

Mark: 9:50

Yes, and that's the really hopeful part, dietary interventions that limit carbs and focus on reducing inflammation are showing some really promising results.

Rachel: 9:57

Like what kinds of diets?

Mark: 9:58

We'll take the autoimmune protocol, or AIP diet. There was a notable study in 2021 looking at patients with Hashimoto's and IBD. Following the AIP diet led to significant improvements in their fatigue, bowel symptoms and even markers of inflammation. That research had NIH backing, by the way.

Rachel: 10:16

AIP. That's quite restrictive initially, isn't it? Focusing on nutrient density and eliminating potential triggers?

Mark: 10:22

It is especially in the elimination phase, but the results suggest it can be really effective for some. Then you also see positive reports, more clinical observations perhaps, from people using ketogenic or paleo-style diets. What kinds of improvements People often report less joint pain, clearer thinking, less brain fog, improved skin conditions. The thinking is this comes from lowering insulin levels, reducing that oxidative stress we talked about and helping to restore gut integrity.

Rachel: 10:48

And for specific conditions like MS or lupus? Anecdotally yes, and for specific conditions like MS or lupus.

Mark: 10:51

Anecdotally, yes, Many patients report fewer flares, less fatigue, when they really minimize sugar, processed carbs and often gluten. Now we definitely need more large-scale formal trials for confirmation, but the pattern in clinical practice in smaller studies is pretty consistent and compelling.

Rachel: 11:10

Okay, so let's try to summarize the research angle. Refined carbs seem to clearly ramp up inflammation and mess with immune regulation. Check. High sugar diets worsen leaky gut and gut bacteria imbalances. Double check. And, on the flip side, diets that are anti-inflammatory, lower in carbs Things like AIP, maybe keto or paleo they show real promise for reducing symptoms and flares.

Mark: 11:33

That sums it up nicely. It's not necessarily a magic bullet for everyone. Responses vary, but the trend is definitely there. Dialing back the refined carbs can make a real difference.

Rachel: 11:42

Which brings us to making this personal Because, as you said, responses vary. Lab testing seems crucial here. Autoimmune conditions aren't just one thing, right, they involve metabolism, gut, immune system.

Mark: 11:57

Exactly. It's a whole system picture. Lab testing is a powerful tool to figure out what's really driving the inflammation for an individual, and then you can use that info to track progress and actually tailor your nutrition, including figuring out your personal tolerance for carbohydrates.

Rachel: 12:07

Okay, so what kind of labs are we talking about? What should people look for?

Mark: 12:11

Well, you'd want to look at a few categories. First, inflammation markers Things like HSCRP, that's high sensitivity C-reactive protein, gives a general sense of systemic inflammation. Esr or SED rate is often used to track activity in conditions like lupus or RA. You can even get more specific with cytokine panels, looking at things like IL-6 or TNF-alpha, those direct inflammatory messengers.

Rachel: 12:35

Right, the ones linked to high blood sugar earlier, and metabolic markers.

Mark: 12:39

Absolutely key. Given the insulin resistance connection. You want fasting insulin and fasting glucose Together. They let you calculate OMAIR, which is a great early indicator of insulin resistance.

Rachel: 12:49

Even before, blood sugar is technically high.

Mark: 12:52

Yes, often years before Then. Hba1c gives you the longer-term view of blood sugar control over about three months, and a lipid panel is important. Too often In insulin resistance you'll see high triglycerides and low HDL cholesterol. That pattern is a red flag for metabolic issues and inflammation.

Rachel: 13:10

Okay, inflammation, metabolism. What about the gut? Can we test for leaky gut and dysbiosis?

Mark: 13:17

You sure can. There's a marker called zonulin which is directly related to intestinal permeability or leaky gut. You can also measure LPS antibodies, which indicate if those bacterial toxins are getting into your bloodstream and triggering immune responses.

Rachel: 13:30

And the gut bacteria themselves.

Mark: 13:32

Yeah, for that. You'd look at comprehensive stool testing Tests like the GI map or Genova's GI effects give you a really detailed picture of your gut microbiome beneficial bacteria, problematic bacteria, yeast parasites, plus markers of gut inflammation and digestion. It's incredibly insightful.

Rachel: 13:48

Wow, it's detailed. And finally the specific autoimmune markers.

Mark: 13:52

Right. So there's the general screening test ANA, antinuclear antibodies. Then, depending on suspicion, you get more specific. For Hashimoto's you'd check TPO and TG, antibodies For RA, rheumatoid factor and anti-CCP. For lupus, anti-DSDNA and anti-SMIF. Celiac has its specific antibodies, MS has others. It depends on the clinical picture.

Rachel: 14:17

So using these tests really gives you objective data. It moves away from guesswork.

Mark: 14:22

Totally. It empowers you. Autoimmune care shouldn't be one size fits all. These labs help pinpoint your specific imbalances and guide dietary changes, including carb intake, for much better control, hopefully fewer flares, and it's great that things like at-home testing options like QuickLab Mobile offers for some of these, make it easier to actually monitor these things.

Rachel: 14:42

Makes it more accessible, less of a hassle.

Mark: 14:44

Exactly Understand your own body's landscape.

Rachel: 14:46

Okay, so, wrapping up our deep dive today, let's just circle back to the core message Autoimmune diseases. Yeah, they're complex, but they're not just random bad luck.

Mark: 14:55

Right Underneath every flare-up, there's usually a system under stress metabolically, immunologically and, as we focused on, often nutritionally.

Rachel: 15:03

And a huge, often missed piece of that nutritional stress excessive carbs, especially the refined processed kinds.

Mark: 15:11

Yeah, just to quickly recap the impact these foods spike blood sugar, sure, but they also disrupt your gut microbiome. They weaken the gut barrier allowing things through, they fuel that low-grade chronic inflammation and they basically wind up an already confused immune system.

Rachel: 15:27

But and this is the crucial takeaway there's really encouraging news here. You actually have more control than maybe you realized.

Mark: 15:33

Absolutely. By shifting towards a diet that's anti-inflammatory, lowering those problem carbs, focuses on gut health, and by using lab testing to personalize and track, you can often really reduce flare frequency, calm down that immune overactivity and get back energy, clarity, stability.

Rachel: 15:50

It's about taking proactive steps.

Mark: 15:52

It really is. So maybe a final thought to leave everyone with Go for it. Autoimmunity might have roots in your genes, sure, but you don't have to feed it. It's worth thinking really hard about what exactly you are feeding your system every day.

Nicolette: 16:06

Thanks for tuning into the Health Pulse. If you found this episode helpful, don't forget to subscribe and share it with someone who might benefit. For more health insights and diagnostics, visit us online at wwwquicklabmobilecom. Stay informed, stay healthy and we'll catch you in the next episode.